Rsulide P 100mg/325mg Tablet

by Rx Healthcare Ltd · Tablet Rx
Generic Name Paracetamol and Nimesulide
Drug Class Non-steroidal anti-inflammatory drug (NSAID) and analgesic
Route Oral
Habit Forming No
Prescription Required (Rx)
Strengths 100mg/325mg
MRP
₹31.25
strip of 10 tablets

About Rsulide P 100mg/325mg Tablet

Rsulide P 100mg/325mg Tablet is a combination medicine that contains two active ingredients: Paracetamol and Nimesulide. It is used to relieve pain and reduce fever. This medicine is often prescribed for conditions like headaches, muscle pain, arthritis, and other inflammatory conditions. It is important to use this medication as directed by your healthcare provider to ensure safety and effectiveness.

Clinical Uses

  • Fever — Helps reduce high body temperature.
  • Headache — Provides relief from mild to moderate headaches.
  • Muscle Pain — Alleviates discomfort from muscle strains and injuries.
  • Arthritis — Reduces pain and inflammation in joint disorders.

Uses & Indications

Primary Uses

  • Pain Relief — Effective for managing mild to moderate pain.
  • Fever Reduction — Helps bring down fever in various conditions.

Secondary Uses

  • Inflammation Control — Reduces inflammation associated with pain conditions.

Off-label Uses

  • Menstrual Pain — Sometimes used to relieve menstrual cramps.

How It Works (Mechanism of Action)

Rsulide P works by combining two medications that help relieve pain and reduce fever. Paracetamol is an analgesic that blocks pain signals in the brain, while Nimesulide is a non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation.

Paracetamol primarily works in the central nervous system, inhibiting the synthesis of prostaglandins, which are chemicals that promote pain and fever. Nimesulide, on the other hand, works by inhibiting the enzyme cyclooxygenase (COX), which is involved in the production of inflammatory substances. Together, they provide effective relief from pain and inflammation.

Key Benefits

  • Effective Pain Relief — Combines two medications for better pain management.
  • Reduces Fever — Quickly lowers body temperature during fever.
  • Anti-inflammatory Properties — Helps reduce swelling and inflammation.

How Long Does It Take to Work?

Initial improvement can be felt within 30 minutes to 1 hour after taking the tablet. Full effects may take a few hours. If symptoms do not improve after 3 days of treatment, consult your healthcare provider.

How to Use

Take the tablet with a full glass of water.

Follow the dosage prescribed by your doctor.

Do not chew or crush the tablet.

Take it at regular intervals for best results.

Do not exceed the recommended dose.

Dosage Guidelines

Adult Dose

  • 1 tablet every 8-12 hours as needed, not exceeding 3 tablets in 24 hours.

Pediatric Dose

Consult a doctor for appropriate dosing in children.

Elderly

Start with a lower dose and monitor closely for side effects.

Administration Instructions

Take with or without food, but consistent use with food may help reduce stomach upset.

Missed Dose

If you miss a dose, take it as soon as you remember. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at once.

Overdose Warning

Overdose can lead to serious health issues. Symptoms may include nausea, vomiting, loss of appetite, confusion, and jaundice. If you suspect an overdose, seek medical help immediately or contact poison control.

Side Effects

Common Side Effects

Nausea

Stomach upset

Dizziness

Less Common Side Effects

Rash

Itching

Serious Side Effects

Liver damage

Severe allergic reactions

When to Seek Immediate Medical Attention

If you experience symptoms like yellowing of the skin or eyes, severe abdominal pain, or difficulty breathing, seek medical help right away.

Contraindications — Who Should Not Use This Medicine

  • Allergy to Nimesulide or Paracetamol — Risk of severe allergic reactions.
  • Severe Liver Disease — Increased risk of liver damage.
  • Active Gastrointestinal Bleeding — Risk of worsening bleeding.

Warnings & Precautions

🤰 Pregnancy
It is not recommended to use this medicine during pregnancy, especially in the third trimester, as it may affect the fetus. Always consult your doctor before taking any medication while pregnant.
🤱 Breastfeeding
Paracetamol is generally considered safe during breastfeeding, but Nimesulide is not recommended. Consult your healthcare provider before using this medication while breastfeeding.
👶 Children
Safety and effectiveness in children have not been established. Consult a doctor for appropriate alternatives and dosing.
🧓 Elderly
Elderly patients may be more sensitive to the effects of this medication. It is important to monitor for side effects and adjust the dose as needed.
🫘 Kidney Disease
Use with caution in patients with kidney impairment. Dose adjustments may be necessary based on kidney function.
🫁 Liver Disease
This medication should be avoided in patients with liver disease. Regular liver function tests may be required for those with mild impairment.
❤️ Heart Disease
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💉 Diabetes
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🩸 Hypertension
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🍷 Alcohol
Alcohol can increase the risk of liver damage when taking this medication. It is advisable to limit or avoid alcohol consumption.
🚗 Driving
This medication may cause dizziness in some individuals. Use caution when driving or operating machinery until you know how it affects you.
🚬 Smoking
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Drug Interactions

Drug-Drug Interactions

Avoid using with other NSAIDs to reduce the risk of side effects.

Be cautious with anticoagulants as they may increase bleeding risk.

Food Interactions

Taking with food may help reduce stomach upset.

Alcohol Interactions

Alcohol can increase the risk of liver damage.

Disease Interactions

Use with caution in patients with liver or kidney disease.

Storage Instructions

Store at room temperature, away from moisture.

Protect from light.

Keep out of reach of children.

Check expiry date before use.

Expert Advice

Clinical Tips

Always follow your doctor's instructions regarding dosage.

Do not take for longer than recommended.

Keep track of your symptoms and report any changes to your doctor.

Stay hydrated while taking this medication.

Avoid alcohol to reduce the risk of liver damage.

Do not share your medication with others.

If symptoms persist, consult your healthcare provider.

Substitute Medicines

Same composition, different brands. Always consult your doctor before switching.

Sources

Last Updated24 Jun 2026
Content Generated24 Jun 2026
⚕️ Medical Disclaimer This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or pharmacist before starting, stopping, or changing any medication. Prices shown are indicative MRP and may vary.
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