Zepler M 150mg/1500mcg Tablet

by Zeuson Medicines Pvt Ltd · Tablet Rx
Generic Name Methylcobalamin and Epalrestat
Drug Class Vitamin B12 analog and Aldose reductase inhibitor
Route Oral
Habit Forming No
Prescription Required (Rx)
Strengths 150mg/1500mcg
MRP
₹218.00
strip of 10 tablets

About Zepler M 150mg/1500mcg Tablet

Zepler M 150mg/1500mcg Tablet is a combination medicine that contains Methylcobalamin and Epalrestat. It is primarily used to manage diabetic neuropathy, a condition that affects the nerves due to diabetes. This medicine helps in reducing nerve pain and improving nerve function. It is suitable for adults suffering from nerve-related issues caused by diabetes.

Clinical Uses

  • Diabetic Neuropathy — A nerve disorder caused by diabetes that leads to pain and discomfort.

Uses & Indications

Primary Uses

  • Diabetic Neuropathy — Helps alleviate nerve pain and improve nerve health in diabetic patients.

Secondary Uses

  • Vitamin Deficiency — May help in cases of vitamin B12 deficiency.

How It Works (Mechanism of Action)

Methylcobalamin is a form of vitamin B12 that helps in the production of red blood cells and maintains healthy nerve cells. It plays a crucial role in the functioning of the nervous system. Epalrestat works by inhibiting the enzyme aldose reductase, which helps in reducing the accumulation of sorbitol in nerve cells, thereby preventing nerve damage caused by high blood sugar levels.

Together, these ingredients work to alleviate symptoms of diabetic neuropathy by improving nerve health and reducing pain. Methylcobalamin supports nerve regeneration, while Epalrestat helps in controlling the complications of diabetes, making this combination effective for managing nerve-related issues.

Key Benefits

  • Reduces Nerve Pain — Helps in decreasing pain associated with diabetic neuropathy.
  • Improves Nerve Function — Supports better nerve health and function.
  • Vitamin Supplementation — Provides essential vitamin B12 for overall health.

How Long Does It Take to Work?

You may start to notice improvements in your symptoms within a few weeks of starting treatment. Full benefits may take several weeks to months. If you do not see any improvement after a few weeks, consult your doctor for further advice.

How to Use

Take the tablet as prescribed by your doctor.

Swallow the tablet whole with a glass of water.

Do not crush or chew the tablet.

Take it at the same time each day for best results.

Dosage Guidelines

Adult Dose

Typically, one tablet daily or as directed by your doctor.

Pediatric Dose

Safety and efficacy in children have not been established.

Elderly

Elderly

  • patients may require careful monitoring and dose adjustment.

Administration Instructions

Take with or without food as directed by your healthcare provider.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up to make up for a missed dose.

Overdose Warning

Overdose may lead to symptoms such as nausea, vomiting, or dizziness. If you suspect an overdose, seek immediate medical help or contact poison control.

Side Effects

Common Side Effects

Nausea

Dizziness

Headache

Less Common Side Effects

Allergic reactions

Skin rash

Serious Side Effects

Severe allergic reactions

Signs of nerve damage

When to Seek Immediate Medical Attention

If you experience severe side effects or signs of an allergic reaction, seek medical help right away.

Contraindications — Who Should Not Use This Medicine

  • Allergy to Ingredients — Do not use if you are allergic to Methylcobalamin or Epalrestat.
  • Severe Kidney Disease — Patients with severe renal impairment should avoid this medication.

Warnings & Precautions

🤰 Pregnancy
This medication is classified as Category C. It should only be used during pregnancy if clearly needed and prescribed by a doctor. Always consult your healthcare provider before taking any medication during pregnancy.
🤱 Breastfeeding
It is not known if this medicine passes into breast milk. Consult your doctor before using it while breastfeeding to ensure safety for your baby.
👶 Children
Safety and effectiveness in children have not been established. Consult a pediatrician for advice on use in children.
🧓 Elderly
Elderly patients may be more sensitive to the effects of this medication. Dose adjustments may be necessary, so consult your doctor.
🫘 Kidney Disease
Use with caution in patients with kidney impairment. Dose adjustments may be needed based on kidney function.
🫁 Liver Disease
Use with caution in patients with liver impairment. Consult your doctor for appropriate dosing.
💉 Diabetes
This medicine is specifically designed for diabetic patients and helps manage nerve-related complications of diabetes.
🍷 Alcohol
Limit alcohol consumption while taking this medication, as it may increase the risk of side effects.
🚗 Driving
This medication may cause dizziness; use caution when driving or operating machinery.

Drug Interactions

Drug-Drug Interactions

Avoid using with other medications that affect blood sugar levels.

Food Interactions

There are no specific food interactions, but a balanced diet is recommended.

Alcohol Interactions

Alcohol may increase the risk of side effects.

Disease Interactions

Consult your doctor if you have a history of kidney or liver disease.

Storage Instructions

Store at room temperature (15-30°C).

Keep away from moisture.

Protect from light.

Keep out of reach of children.

Check expiry date before use.

Expert Advice

Clinical Tips

Take the full course as prescribed by your doctor.

Do not stop taking the medication without consulting your healthcare provider.

Maintain a healthy diet and lifestyle to support treatment.

Regularly monitor your blood sugar levels.

Report any unusual side effects to your doctor.

Stay hydrated while on this medication.

Keep all follow-up appointments with your healthcare provider.

Substitute Medicines

Same composition, different brands. Always consult your doctor before switching.

Sources

Last Updated22 Jun 2026
Content Generated22 Jun 2026
⚕️ Medical Disclaimer This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or pharmacist before starting, stopping, or changing any medication. Prices shown are indicative MRP and may vary.
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