Zextine-Forte Tablet CR

by Holy Evolution Pharma · Tablet Schedule H
Generic Name Clonazepam and Paroxetine
Drug Class Benzodiazepine and Selective Serotonin Reuptake Inhibitor (SSRI)
Route Oral
Habit Forming Yes
Prescription Required (Rx)
Strengths 0.5mg Clonazepam, 25mg Paroxetine
MRP
₹130.00
strip of 10 tablet ir

About Zextine-Forte Tablet CR

Zextine-Forte Tablet CR is a combination medication that contains Clonazepam and Paroxetine. It is primarily used to treat anxiety and depression. Clonazepam helps to reduce anxiety, while Paroxetine works to improve mood. This medicine is prescribed for adults who are experiencing these mental health conditions.

Clinical Uses

  • Anxiety Disorders — Helps to manage symptoms of anxiety.
  • Depression — Aids in alleviating feelings of sadness and hopelessness.

Uses & Indications

Primary Uses

  • Anxiety Disorders — Effective in reducing anxiety symptoms.
  • Major Depressive Disorder — Used to treat severe depression.

Secondary Uses

  • Panic Disorder — Helps to control panic attacks.
  • Obsessive-Compulsive Disorder — Can assist in managing obsessive thoughts.

How It Works (Mechanism of Action)

Zextine-Forte Tablet CR works by combining two active ingredients. Clonazepam is a benzodiazepine that acts on the brain to produce a calming effect, helping to reduce anxiety. Paroxetine is an SSRI that increases levels of serotonin, a neurotransmitter that helps improve mood.

Clonazepam enhances the effect of a natural chemical in the body called GABA, which helps to calm nerve activity. Paroxetine inhibits the reuptake of serotonin in the brain, making more serotonin available to improve mood and reduce anxiety.

Key Benefits

  • Reduces Anxiety — Helps calm the mind and reduce feelings of anxiety.
  • Improves Mood — Enhances overall mood and emotional well-being.
  • Long-lasting Effects — Provides extended relief from symptoms.

How Long Does It Take to Work?

Initial improvement in symptoms may be noticed within a few days, but it can take several weeks to feel the full benefits. The typical duration of treatment is determined by your doctor based on your condition. If you do not see any improvement after 4-6 weeks, consult your doctor.

How to Use

Take the tablet as prescribed by your doctor.

Swallow the tablet whole with a glass of water.

Do not crush or chew the tablet.

Take it at the same time each day for best results.

Do not stop taking it suddenly without consulting your doctor.

Dosage Guidelines

Adult Dose

The usual dose is one tablet daily, or as directed by your doctor.

Pediatric Dose

Safety and efficacy in children have not been established.

Elderly

Older adults may require a lower dose; consult your doctor.

Administration Instructions

Take with or without food, but maintain consistency.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose. Do not take two doses at the same time.

Overdose Warning

Overdose symptoms may include extreme drowsiness, confusion, or breathing problems. If you suspect an overdose, seek immediate medical help or contact poison control.

Side Effects

Common Side Effects

Drowsiness

Dizziness

Nausea

Less Common Side Effects

Dry mouth

Weight gain

Insomnia

Serious Side Effects

Severe allergic reactions

Suicidal thoughts

Severe mood changes

When to Seek Immediate Medical Attention

If you experience any serious side effects or signs of an allergic reaction, seek medical help right away.

Contraindications — Who Should Not Use This Medicine

  • Allergy to Ingredients — Do not use if you are allergic to Clonazepam or Paroxetine.
  • Severe Liver Disease — Not recommended for patients with severe liver problems.
  • History of Substance Abuse — Caution is advised due to potential for dependence.

Warnings & Precautions

🤰 Pregnancy
This medication is classified as Category D, meaning there is evidence of risk to the fetus. Consult your doctor if you are pregnant or planning to become pregnant.
🤱 Breastfeeding
Clonazepam and Paroxetine can pass into breast milk. Consult your doctor before using this medication while breastfeeding.
👶 Children
The safety and effectiveness of this medication in children have not been established. It is not recommended for use in pediatric patients.
🧓 Elderly
Elderly patients may be more sensitive to the effects of this medication. A lower dose may be necessary.
🫘 Kidney Disease
Use with caution in patients with kidney problems. Dose adjustments may be needed based on kidney function.
🫁 Liver Disease
Use with caution in patients with liver impairment. Dose adjustments may be necessary.
🍷 Alcohol
Alcohol can increase drowsiness and dizziness. It is advisable to avoid alcohol while taking this medication.
🚗 Driving
This medication may cause drowsiness, affecting your ability to drive or operate machinery.

Drug Interactions

Drug-Drug Interactions

Avoid taking with other sedatives or tranquilizers.

Consult your doctor if you are taking antidepressants.

Food Interactions

There are no specific food interactions, but maintain a consistent diet.

Alcohol Interactions

Avoid alcohol as it can enhance side effects.

Disease Interactions

Use with caution in patients with a history of substance abuse or liver disease.

Storage Instructions

Store at room temperature.

Keep away from moisture.

Protect from light.

Keep out of reach of children.

Check the expiry date before use.

Expert Advice

Clinical Tips

Take the medication exactly as prescribed.

Do not stop taking it suddenly; consult your doctor first.

Keep track of any side effects and report them to your doctor.

Attend regular follow-up appointments with your doctor.

Do not share your medication with others.

Maintain a healthy lifestyle, including diet and exercise.

Be cautious when driving or operating machinery.

Substitute Medicines

Same composition, different brands. Always consult your doctor before switching.

Sources

Last Updated24 Jun 2026
Content Generated24 Jun 2026
⚕️ Medical Disclaimer This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or pharmacist before starting, stopping, or changing any medication. Prices shown are indicative MRP and may vary.
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