Zidshot TZ 1000mg/125mg Injection

Zidshot TZ 1000mg/125mg Injection is a combination antibiotic used to treat a variety of bacterial infections. It contains Ceftazidime, a cephalosporin antibiotic, and Tazobactam, a beta-lactamase inhibitor. This medication is typically used in hospitals for serious infections that require intravenous administration. It is effective against a wide range of bacteria and is often used in cases where other antibiotics may not work. Patients with severe infections, such as those affecting the lungs, urinary tract, skin, and abdomen, may benefit from this treatment.

• Severe Bacterial Infections — Used to treat serious infections caused by susceptible bacteria.
• Respiratory Tract Infections — Effective against pneumonia and other lung infections.
• Urinary Tract Infections — Treats complicated infections of the urinary system.
• Skin and Soft Tissue Infections — Used for severe skin infections.
• Intra-abdominal Infections — Treats infections within the abdominal cavity.

Primary Uses

Treatment of severe bacterial infections.

Management of hospital-acquired infections.

Secondary Uses

Used in combination with other antibiotics for mixed infections.

Off-label Uses

May be used in certain cases of resistant infections under medical supervision.

Zidshot TZ works by combining two active ingredients: Ceftazidime, which disrupts the bacterial cell wall, and Tazobactam, which inhibits enzymes that some bacteria produce to resist antibiotics. Together, they effectively kill bacteria and prevent the spread of infection.

Scientifically, Ceftazidime is a third-generation cephalosporin that binds to penicillin-binding proteins, inhibiting the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls. Tazobactam is a beta-lactamase inhibitor that protects Ceftazidime from degradation by beta-lactamase enzymes produced by resistant bacteria.

• Broad-Spectrum Activity — Effective against a wide range of bacteria.
• Combination Therapy — The addition of Tazobactam enhances the effectiveness of Ceftazidime.
• Intravenous Administration — Allows for rapid delivery and action in severe infections.

Initial improvement in symptoms can be seen within a few days of starting treatment. The full course of treatment usually lasts 7-14 days, depending on the infection type and severity. If there is no improvement within 3-5 days, consult your doctor.

Ensure the injection is administered by a healthcare professional.

The injection is given intravenously, usually in a hospital setting.

Follow the dosing schedule as prescribed by your doctor.

Do not skip doses to ensure the effectiveness of the treatment.

Adult Dose

Typically 1-2 grams of Ceftazidime every 8-12 hours, adjusted based on infection severity and kidney function.

Pediatric Dose

Dose is based on body weight and the type of infection.

Elderly

Dose adjustments may be necessary due to potential kidney function decline.

Administration Instructions

Administered intravenously by a healthcare professional.

Common Side Effects

Nausea and vomiting

Diarrhea

Injection site reactions

Less Common Side Effects

Headache

Dizziness

Serious Side Effects

Severe allergic reactions

Kidney problems

Severe diarrhea

When to Seek Immediate Medical Attention

If you experience difficulty breathing, swelling of the face or throat, or severe rash.

• Allergy to Cephalosporins — Patients with known allergies to cephalosporin antibiotics should not use this medication.
• Severe Kidney Dysfunction — Use with caution or avoid in patients with severe renal impairment.

Drug-Drug Interactions

• Aminoglycosides — Increased risk of kidney damage.
• Diuretics — May enhance nephrotoxic effects.

Food Interactions

No significant food interactions noted.

Alcohol Interactions

Avoid alcohol to prevent increased side effects.

Disease Interactions

• Renal Dysfunction — Requires dose adjustment.

Store at room temperature below 25°C.

Keep away from moisture.

Protect from light.

Keep out of reach of children.

Check expiry date before use.