Zogest 500mg Injection

by Zorion Drugs & Herbs Pvt. Ltd. · Injection Rx
Generic Name Hydroxyprogesterone
Drug Class Progestin
Route Intramuscular
Habit Forming No
Prescription Required (Rx)
Strengths 500mg
MRP
₹192.00
vial of 2 ml Injection

About Zogest 500mg Injection

Zogest 500mg Injection contains Hydroxyprogesterone, a type of hormone known as a progestin. It is primarily used to help prevent preterm birth in pregnant women who have had a previous preterm birth. This medication is administered via injection by a healthcare professional. It is important for patients to follow their doctor's instructions and attend all scheduled appointments to ensure the best outcome.

Clinical Uses

  • Prevention of Preterm Birth — Used in pregnant women who have had a previous preterm birth to help prevent another early delivery.

Uses & Indications

Primary Uses

Prevention of preterm birth in women with a history of early delivery.

Secondary Uses

Off-label Uses

How It Works (Mechanism of Action)

Hydroxyprogesterone works by supplementing the body with a hormone similar to progesterone, which is important for maintaining pregnancy.

Scientifically, it binds to progesterone receptors in the body, helping to maintain the uterine lining and prevent contractions, thus reducing the risk of preterm birth.

Key Benefits

  • Reduces Risk of Preterm Birth — Helps in lowering the chances of delivering a baby prematurely.
  • Hormonal Support — Provides necessary hormonal support during pregnancy.

How Long Does It Take to Work?

Initial improvements in reducing the risk of preterm birth can be observed after a few weeks of treatment. The full treatment duration is typically until 37 weeks of pregnancy. If there is no improvement or if symptoms worsen, consult your doctor immediately.

How to Use

Ensure the injection is administered by a healthcare professional.

Follow the schedule provided by your doctor, usually once a week.

Attend all your prenatal appointments for monitoring.

Dosage Guidelines

Adult Dose

Typically, 500mg once a week as directed by a healthcare provider.

Pediatric Dose

Elderly

Administration Instructions

Administered intramuscularly by a healthcare professional.

Missed Dose

If you miss a dose, contact your healthcare provider as soon as possible to reschedule. Do not double the dose to make up for the missed one.

Overdose Warning

In case of overdose, seek immediate medical attention. Symptoms may include nausea, vomiting, or dizziness. Contact emergency services or poison control for assistance.

Side Effects

Common Side Effects

Pain at the injection site

Nausea

Headache

Less Common Side Effects

Swelling

Itching

Serious Side Effects

Severe allergic reactions

Blood clots

When to Seek Immediate Medical Attention

If you experience symptoms of an allergic reaction such as rash, itching, or swelling.

Contraindications — Who Should Not Use This Medicine

  • Allergy to Hydroxyprogesterone — Patients with known allergies should not use this medication.
  • Uncontrolled Hypertension — May worsen the condition.
  • Liver Disease — Can affect liver function.

Warnings & Precautions

🤰 Pregnancy
Category B. Generally considered safe for use during pregnancy to prevent preterm birth, but should only be used under medical supervision.
🤱 Breastfeeding
Consult your doctor before using this medication while breastfeeding, as it may pass into breast milk.
👶 Children
Not recommended for use in children. This medication is intended for pregnant women with a history of preterm birth.
🧓 Elderly
Not applicable as this medication is intended for use in pregnant women.
🫘 Kidney Disease
No specific dose adjustment is needed for patients with renal impairment, but consult your doctor for personalized advice.
🫁 Liver Disease
Use with caution in patients with liver impairment. Dose adjustment may be necessary.
💉 Diabetes
Patients with diabetes should monitor their blood sugar levels closely while using this medication.
🍷 Alcohol
Avoid alcohol as it may interfere with the effectiveness of the medication.
🚗 Driving
This medication does not typically affect your ability to drive.

Drug Interactions

Drug-Drug Interactions

Rifampin

Carbamazepine

Food Interactions

Alcohol Interactions

Alcohol may reduce the effectiveness of the medication.

Disease Interactions

Liver disease

Hypertension

Storage Instructions

Store at room temperature between 20-25°C (68-77°F).

Keep away from moisture.

Protect from light.

Keep out of reach of children.

Check expiry date before use.

Expert Advice

Clinical Tips

Complete the full course as prescribed by your doctor.

Attend all scheduled prenatal appointments.

Inform your doctor of any other medications you are taking.

Do not self-administer the injection; it should be done by a healthcare professional.

Report any side effects to your doctor immediately.

Maintain a healthy lifestyle during pregnancy.

Do not consume alcohol while on this medication.

Substitute Medicines

Same composition, different brands. Always consult your doctor before switching.

Frequently Asked Questions

What should I do if I miss a dose?
If you miss a dose, contact your healthcare provider for guidance on what to do next.
Can Zogest affect my menstrual cycle?
Yes, Zogest can help regulate menstrual cycles and may be used for menstrual disorders.
Is Zogest safe for long-term use?
Long-term use should be monitored by a healthcare provider to assess benefits and risks.

Sources

The information on this page about Zogest 500mg Injection has been compiled and verified using the following authoritative medical sources and references. This content is AI-assisted and cross-checked against published clinical and pharmacological literature.

  1. Manufacturer – Zogest 500mg Injection Prescribing Information and Product Monograph
  2. NHSHydroxyprogesterone
  3. Mayo ClinicProgesterone (Oral Route, Injection Route)
  4. MedlinePlusHydroxyprogesterone Injection
  5. Drugs.comHydroxyprogesterone Caproate
Last Updated13 Jun 2026
Content Generated13 Jun 2026
⚕️ Medical Disclaimer This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always consult your doctor or pharmacist before starting, stopping, or changing any medication. Prices shown are indicative MRP and may vary.
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